• British medical bulletin · Jan 2009

    Review

    Bone health in HIV infection.

    • Emily Pollock, Angelos-Emmanouil Klotsas, Juliet Compston, and Effrossyni Gkrania-Klotsas.
    • Clinical School of Medicine, University of Cambridge, Cambridge, UK.
    • Br. Med. Bull. 2009 Jan 1; 92: 123-33.

    IntroductionOsteoporosis is among the chronic problems emerging as the human immunodeficiency virus (HIV)-positive population ages.Sources Of DataWe reviewed the English language bibliography using Pubmed 2.0, Web of Science and Embase for relevant abstracts and articles.Areas Of AgreementThe prevalence of low bone mineral density (BMD) and fracture is increased in the HIV-positive population.Areas Of ControversyThe pathogenesis is multifactorial; there is some evidence that HIV infection is an independent risk factor and that highly active antiretroviral therapy has adverse skeletal effects.Growing PointsPhysicians should routinely review the bone health of all HIV patients.Areas Timely For Developing ResearchMore studies of the mechanisms of bone loss, the skeletal effects of antiretroviral therapy and the therapeutic outcome of bone-protective therapy in HIV-positive individuals are needed.

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