• Der Schmerz · Feb 2021

    [Off-label use in palliative medicine].

    • Constanze Rémi and Christina Gerlach.
    • Klinik und Poliklinik für Palliativmedizin, Arzneimittelinformation, Klinikum der Universität München, Marchioninistr. 15, 81377, München, Deutschland. constanze.remi@med.uni-muenchen.de.
    • Schmerz. 2021 Feb 1; 35 (1): 61-73.

    AbstractPalliative care serves to improve the quality of life in patients suffering from incurable diseases. Pharmacotherapy of distressing symptoms plays an important role. Off-label use refers to the use of drugs outside the marketing authorization. In addition to the indications off-label use may also be due to duration of treatment, route of administration and the admixture of substances. Off-label use is common in palliative and hospice care and is probably unavoidable in many cases. For treatment planning and realization of off-label therapy in clinical practice, patient-related aspects, information, therapy monitoring and documentation of therapy effects should be considered in addition to drug-related information. Only in this way it is possible to offer a scientifically adequate, appropriate and economic therapy that is linked to an appropriate risk-benefit ratio for the individual patient. Due to the lack of authorization studies, reporting is of particular importance.

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