• Life sciences · Feb 2019

    Dehydroepiandrosterone attenuates pulmonary artery and right ventricular remodeling in a rat model of pulmonary hypertension due to left heart failure.

    • Yi-Tao Zhang, Jiao-Jie Xue, Qing Wang, Shi-Yao Cheng, Zhi-Chong Chen, Hua-Yang Li, Jia-Jie Shan, Kang-Lin Cheng, and Wei-Jie Zeng.
    • Cardiovascular Department of the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
    • Life Sci. 2019 Feb 15; 219: 82-89.

    AimPulmonary hypertension due to left heart failure (PH-LHF) is the most common cause of pulmonary hypertension. However, therapies for PH-LHF are lacking. Therefore, we investigated the effects and potential mechanism of dehydroepiandrosterone (DHEA) treatment in an experimental model of PH-LHF.Main MethodPH-LHF was induced in rats via ascending aortic banding. The rats then received daily DHEA from Day 1 to Day 63 for the prevention protocol or from Day 49 to Day 63 for the reversal protocol. Other ascending aortic banding rats were left untreated to allow development of PH and right ventricular (RV) failure. Sham ascending aortic banding rats served as controls.Key FindingSignificant increases in mean pulmonary arterial pressure (mPAP) and right ventricular end-diastolic diameter (RVEDD) were observed in the PH-LHF group. Therapy with DHEA prevented LHF-induced PH and RV failure by preserving mPAP and preventing RV hypertrophy and pulmonary artery remodeling. In preexisting severe PH, DHEA attenuated most lung and RV abnormalities. The beneficial effects of DHEA in PH-LHF seem to result from depression of the STAT3 signaling pathway in the lung.SignificantDHEA not only prevents the development of PH-LHF and RV failure but also rescues severe preexisting PH-LHF.Copyright © 2018 Elsevier Inc. All rights reserved.

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