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Asian Cardiovasc Thorac Ann · Nov 2020
Case ReportsWarfarin-induced toxic epidermal necrolysis after mitral valve replacement.
- Taiyo Kuroda, Yukifusa Yokoyama, Masao Yamada, Satoshi Yuhara, Hiroki Hasegawa, and Jun Yokote.
- Department of Thoracic and Cardiovascular Surgery, 37124Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
- Asian Cardiovasc Thorac Ann. 2020 Nov 1; 28 (9): 601-603.
AbstractStevens-Johnson syndrome and toxic epidermal necrolysis are rare diseases that cause acute destruction of the epithelium of the skin and mucous membranes, almost always attributable to drugs. However, warfarin-induced Stevens-Johnson syndrome and toxic epidermal necrolysis is extremely rare. We report the case of 71-year-old woman who died due to destructive erosion all over her skin and mucous membranes. She had received a mitral valve prosthesis, and warfarin was prescribed for antithrombotic therapy. A lymphocyte transformation test for drug hypersensitivity and the clinical history confirmed this phenomenon as warfarin-induced toxic epidermal necrolysis.
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