• Andre Dias, Ivan J Núñez Gil, Francesco Santoro, John E Madias, Francesco Pelliccia, Natale Daniele Brunetti, Elena Salmoirago-Blotcher, Scott W Sharkey, Ingo Eitel, Yoshihiro J Akashi, Ibrahim El-Battrawy, Emiliana Franco, Ibrahim Akin, Milosz Jaguszewski, Dana Dawson, Vincent M Figueredo, L Christian Napp, Thomas Emil Christensen, Kathy Hebert, Itsik Ben-Dor, Yuichi Ozaki, Héctor M García-Garcia, Alexandre H Kajita, Takashi Akasaka, Satoshi Kurisu, Amir Lerman, and Ron Waksman.
• Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, United States of America; Department of Cardiology, Einstein Medical Center, Philadelphia, PA, United States of America.
• Cardiovasc Revasc Med. 2019 Jan 1; 20 (1): 70-79.

AbstractTakotsubo syndrome (TTS) is an acute cardiac condition independent of epicardial coronary obstruction that mimics acute coronary syndrome and is characterized by acute heart failure with reversible ventricular motion abnormalities. This consensus paper is the result of a multinational effort aiming to summarize the current state of the art on TTS. Experts in the field provide a thorough and detailed review of this syndrome. Several novel and unique sections are emphasized in this document, including the current state of the art on genetics of takotsubo syndrome, microRNAs (miRs), racial differences, role of cardiac spectroscopy and intracoronary imaging, as well as mechanical circulatory support. In part 1 of this two-part manuscript, we discuss how TTS came to be known, several patterns and forms it can take in patients, epidemiology and pathophysiology of the syndrome, and clinical presentation.Copyright © 2018 Elsevier Inc. All rights reserved.

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