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- Yisi Liu, Fangqin Wu, Ying Wu, Malcolm Elliott, Wei Zhou, Ying Deng, Dianxu Ren, and Haibo Zhao.
- Capital Medical University, Beijing, PR China.
- Transl Res. 2021 Jul 1; 233: 16-31.
AbstractClinical observation and ex vivo studies have established a strong association between inflammation and postoperative atrial fibrillation (POAF). However, it is unclear whether the inflammatory phenotype is causally linked to this event or is an epiphenomenon, and it is not known which inflammatory meditators may increase susceptibility to POAF. The limitations of available animal models of spontaneous POAF (sPOAF) makes it difficult to select an experimental system. Here, we provide experimental and clinical evidence for mechanistic involvement of interleukin-6 (IL-6) in sPOAF.Copyright © 2021. Published by Elsevier Inc.
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