• Mojtaba Khazaei, Mozhdeh Khosravi, Shahir Mazaheri, Mehrdokht Mazdeh, Masoud Ghiasian, Mohammad Taheri, and Soudeh Ghafouri-Fard.
• 1Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; 2Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran; 3Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
• Acta Clin Croat. 2020 Jun 1; 59 (2): 223-226.

AbstractOcclusion of the initial segment of internal carotid artery is the most common reason for vascular events in the brain. The purpose of this study was to investigate the effect of one-year treatment with atorvastatin on intima-media thickness (IMT) of carotid arteries as a measure of atherosclerosis in stroke patients. In this prospective interventional study, 44 patients with ischemic stroke were investigated. Patients were treated with atorvastatin 40 mg once a day for one year. IMT of carotid arteries was measured by extracranial Doppler ultrasonography in the distal part of the common carotid artery at the beginning of the study, at 6 months and one year of treatment with atorvastatin. The IMT of both right and left carotid arteries decreased after 6- and 12-month atorvastatin treatment. Based on the results of this study, long-term administration of atorvastatin was associated with reduction in carotid artery IMT in patients with ischemic stroke. Such a decrease in IMT may prevent subsequent stroke or cardiovascular events in these patients.

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