• Acta clinica Croatica · Jun 2020

    Review Case Reports

    Brucellosis in pregnancy: case reports with different outcomes in an endemic region.

    • Mile Bosilkovski, Marjan Stojovski, Dijana Siskova, Aleksandar Ridov, Emilija Kostoska, and Kiril Krstevski.
    • 1Medical Faculty, Ss Cyril and Methodius University, Skopje, Republic of Macedonia; 2University Hospital of Obstetrics and Gynecology, Skopje, Republic of Macedonia; 3Department of Infectious Diseases, Shtip Medical Center, Shtip, Republic of Macedonia; 4Department of Infectious Diseases, Kavadarci Medical Center, Kavadarci, Republic of Macedonia; 5Department of Infectious Diseases, Prilep Medical Center, Prilep, Republic of Macedonia; 6Faculty of Veterinary Medicine, Ss Cyril and Methodius University, Skopje, Republic of Macedonia.
    • Acta Clin Croat. 2020 Jun 1; 59 (2): 338-343.

    AbstractDifferent outcomes of brucellosis in pregnancy regarding the fetus/neonate and the mother are described. Medical records of five pregnant women with brucellosis were retrospectively analyzed. Patients were treated in several departments of infectious diseases in the Republic of Macedonia between 1995 and 2009. The diagnosis of brucellosis was based on clinical findings compatible with the disease supported by detection of specific antibodies. Pregnancy outcomes in patients were as follows: spontaneous abortion, intrauterine fetal death, premature delivery in two cases (one with twin pregnancy) and term delivery. One of the women experienced relapse. Follow-up results of neonates showed no infection and their normal growth and development. Brucellosis, especially if acquired in early pregnancy, can have an impact on pregnancy outcome. In endemic regions, in pregnant women with persisting fever and unspecific manifestations one should always have in mind brucellosis. In these areas, cases with unexplained spontaneous abortion, intrauterine fetal death and premature delivery should also be investigated for brucellosis.

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