• Ryosuke Fujii, Takaaki Kondo, Mineko Tsukamoto, Sayo Kawai, Tae Sasakabe, Mariko Naito, Yoko Kubo, Rieko Okada, Takashi Tamura, Asahi Hishida, Jun Ueyama, Yumi Hayashi, Joji Ohnishi, Nobuyuki Hamajima, Kenji Takeuchi, and Kenji Wakai.
• Department of Preventive Medical Sciences, Fujita Health University School of Medical Sciences, Toyoake, Japan; Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: rfujii@fujita-hu.ac.jp.
• Nutrition. 2021 Apr 1; 84: 111114.

ObjectivesAlthough consumption of vegetable and 100% fruit juices are an acceptable alternative for vegetable and fruit intake, information about their actual effects on kidney function is sparse. The aim of this study was to determine the association between the consumption of vegetable and fruit juices and changes in kidney function in a Japanese population over a 5-y period.MethodsIn this prospective study, we analyzed 2755 Japanese (742 men and 2013 women) individuals who participated in both the baseline and follow-up surveys in the Daiko study (a study within the Japan Multi-Institutional Collaborative Cohort study). Estimated glomerular filtration rate (eGFR) was calculated by age, sex, and serum creatinine level. For each beverage, we categorized all participants into four groups-rare (rarely consumed), low (≤2 cups/wk), moderate (3-4 cups/wk), or frequent (≥5 cups/wk) consumers of the beverage-based on a food frequency questionnaire.ResultsThe mean baseline and follow-up eGFR (SD) were 82.4 (14.6) and 72.2 (12.6), respectively. In fully adjusted regression analyses, moderate consumption of vegetable juice was associated a lower decline in eGFR compared with the rare consumption group (β = -1.30; P = 0.01). Moreover, stratified analyses revealed that this significant association remained in those who were young, female, non-obese, normotensive, smoked cigarettes, consumed alcohol, or exercised. However, no significant association was found in analyses for fruit juices.ConclusionsThis 5-y prospective study suggested an association between self-reported moderate consumption of vegetable juice and changes (possibly smaller decline) in kidney function in a relatively healthy Japanese population.Copyright © 2020 Elsevier Inc. All rights reserved.

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