• S Bilgin, G Aktas, G Kahveci, B M Atak, O Kurtkulagi, and DumanT TaslamaciogluTT.
• Bratisl Med J. 2021 Jan 1; 122 (2): 116-119.

ObjectivesFrailty is a common problem in patients with type 2 diabetes mellitus (T2DM). It is considered to be associated with inflammation. Novel markers derived from hemogram, such as neutrophil/lymphocyte ratio (NLR) and mean platelet volume/lymphocyte ratio (MPVLR), are proposed as inflammatory markers. In present study, we aimed to compare NLR and MPVLR levels of frail patients with T2DM to non‑frail diabetic subjects.MethodsDiabetic subjects were grouped in frail and non-frail groups according to the Edmonton Frail Scale. General characteristics and laboratory data of the frail and non-frail groups were compared.ResultsThe MPVLR of the frail (3.9 [1.4-13.2] %) group was significantly higher than that of the non-frail (3.4 [1.5-6.9] %) group (p = 0.02). MPVLR was positively and significantly correlated with Edmonton Frail Scale score (r = 0.21, p = 0.03). A MPVLR level greater than 3.41 % has 71 % sensitivity and 51 % specifity in predicting frailty.ConclusionWe suggest that elevated MPVLR could be a finding that marks frailty in diabetic subjects. Inexpensive and easy‑to‑assess nature of the MPVLR may be useful in predicting frailty in type 2 diabetic population (Tab. 2, Fig. 1, Ref. 32).

8 keywords...

hide…