• Arch Med Sci · Jan 2021

    Prognostic value of the PIK3CA, AKT, and PTEN mutations in oral squamous cell carcinoma: literature review.

    • Anna Starzyńska, Aleksandra Sejda, Paulina Adamska, Giulia Marvaso, Monika Sakowicz-Burkiewicz, Łukasz Adamski, and Barbara A Jereczek-Fossa.
    • Department of Oral Surgery, Medical University of Gdansk, Gdansk, Poland.
    • Arch Med Sci. 2021 Jan 1; 17 (1): 207-217.

    AbstractOver 260,000 (2013) new oral squamous cell carcinoma (OSCC) cases are reported annually worldwide. Despite development in OSCC management, the outcome is still unsatisfactory. Identification of new molecular markers may be of use in prevention, prognosis, and choice of an appropriate therapy. The intracellular molecular signalling pathway of phosphatidyl-inositol-3-kinase is involved in the process of cell growth, differentiation, migration, and survival. The main components of this pathway: PIK3CA (phosphatidylinositol-4,5-bisphosphate-3-kinase catalytic subunit α), PTEN (phosphatase and tensin homologue deleted on chromosome 10), and AKT (serine-threonine kinase) are potential objects of research when introducing new therapeutic agents. The aim of this paper is to evaluate the PIK3CA, PTEN, and AKT gene mutations as prognostic factors in OSCC and to describe their role in aggressive disease progression. This is crucial for oral cancer biology understanding and for indicating which direction new clinical treatments should take.Copyright: © 2020 Termedia & Banach.

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