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- Donald M Lyall, Joey Ward, Maciej Banach, George Davey Smith, Jason G Gill, Jill P Pell, Michael V Holmes, and Naveed Sattar.
- Institute of Health and Wellbeing, University of Glasgow, Scotland, UK.
- Arch Med Sci. 2021 Jan 1; 17 (1): 241244241-244.
IntroductionPCSK9 inhibitors lower low-density lipoprotein (LDL) cholesterol and are efficacious at reducing vascular disease, however questions remain about potential effects on cognitive function.MethodsWe examined the association of genetic variants in PCSK9 with continuous measures of cognitive ability in UK Biobank. Six independent polymorphisms in PCSK9 were used in up to 337,348 individuals.ResultsThe PCSK9 allele score was associated with a lower risk of CHD, and weakly with worse log reaction time.ConclusionsWe are unable to rule out meaningful associations of PCSK9 genetic variants with cognition, emphasising the potential need for continued pharmacovigilance for patients currently treated with PCSK9 inhibitors.Copyright: © 2021 Termedia & Banach.
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