• Nilgün Alptekinoğlu Mendil, Şahin Temel, Recep Civan Yüksel, Kürşat Gündoğan, Bülent Eser, Leylagül Kaynar, and Murat Sungur.
• Department of Critical Care Medicine, Erciyes University Medical School, Kayseri, Turkey
• Turk J Med Sci. 2021 Aug 30; 51 (4): 1756-1763.

Background/AimHigh flow nasal cannula (HFNC) was mostly used in intensive care units (ICUs) with few studies in other departments. We hypothesized that HFNC applied at wards is beneficial for acute respiratory failure in hematological malignancy patients.Materials And MethodsThe study is a single center, randomized controlled study. Inclusion criteria were hypoxemic respiratory failure and hematological malignancy. Patients were randomized to either venturi mask/nasal cannula oxygen treatment or HFNC.ResultsOne hundred patients were included in the study. Median age was 58.5 (18–86) years and APACHE II score was 17 (5–29). HFNC group was 51 patients and the oxygen treatment group 49 patients. P/F ratios were similar between the groups throughout the study period. Endotracheal intubation was required in 10 (20.0%) patients in oxygen group and 17 (33.0%) patients in HFNC group (p = 0.14). A total of 17 (35.0%) patients in oxygen group and 17 (33.0%) patients in HFNC group received noninvasive mechanical ventilation (p = 0.97). Median VAS comfort scores at the 2nd and 24th hours were not different between groups. The 28-day mortality rate was 36.7% (18 deaths) in the standard group and 45.0% (23 deaths) in the HFNC group (p = 0.39).ConclusionHFNC applied in wards is not superior to standard oxygen treatment for acute respiratory failure in hematological malignancy patients.This work is licensed under a Creative Commons Attribution 4.0 International License.

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