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- M Terada, M N Islam, Z Tun, K Honda, C Wakasugi, T Shinozuka, J Yanagida, T Yamamoto, and Y Kuroiwa.
- Department of Legal Medicine, Osaka University Medical School, Japan.
- J Anal Toxicol. 1996 Sep 1; 20 (5): 318-22.
AbstractA sensitive method for simultaneous determination of ester-type local anesthetic drugs (procaine, tetracaine, and T-caine) has been developed using wide-bore capillary gas chromatography with nitrogen-phosphorus detection (GC-NPD). The extraction procedure, the experimental conditions for heptafluorobutyryl (HFB) derivative formation, and the percentage of the ester-type local anesthetic drugs from the human serum are described. The HFB derivatives of ester-type local anesthetic drugs showed sensitivity of approximately 2-3 fold higher than that without derivatization. The detection limits of HFB derivatives of the ester-type local anesthetic drugs were approximately 60-70 pg on column. Recoveries from the human serum were 85-94%. This method could be used to determine concentrations as low as 24-28 ng/mliters of the ester-type local anesthetic drugs.
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