• Aust Fam Physician · Aug 2008

    Case Reports

    Iatrogenic neuropsychiatric syndromes.

    • Keat Choong and Razvan A Ghiculescu.
    • Princess Alexandra Hospital, Department of Clinical Pharmacology, Brisbane, Queensland. keat_choong@health.qld.gov.au
    • Aust Fam Physician. 2008 Aug 1; 37 (8): 627-9.

    BackgroundAlthough tramadol induced neuropsychiatric toxicity, dependence and withdrawal have been extensively reported in chronic pain sufferers, such cases continue to surface in clinical practice.ObjectiveWe describe two cases of atypical withdrawal after abrupt discontinuation of tramadol and a case of serotonin syndrome. The outcome was favourable in all three cases.DiscussionPatients and prescribers are reminded of the risk of severe morbidity including seizures associated with tramadol withdrawal. Serotonin syndrome can be precipitated with tramadol use especially in combination with other serotonergic drugs.

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