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Br J Clin Pharmacol · Nov 1992
Plasma morphine-3-glucuronide, morphine-6-glucuronide and morphine concentrations in patients receiving long-term epidural morphine.
- J J Schneider, P J Ravenscroft, J D Cavenagh, A M Brown, and J P Bradley.
- Department of Clinical Pharmacology, Princess Alexandra Hospital, Brisbane, Qld., Australia.
- Br J Clin Pharmacol. 1992 Nov 1; 34 (5): 431-3.
AbstractPlasma morphine concentrations were measured in five cancer patients receiving long-term epidural morphine administration. Peak concentrations were observed within 1 h of dosage and concentrations then declined biexponentially. Plasma morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) concentrations were measured in two patients and plasma M3G concentrations were observed to be much higher than plasma M6G and morphine concentrations. Peak plasma M6G concentrations occurred within 1.0 h of dosing and plasma M6G concentrations then remained higher than plasma morphine concentrations.
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