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- A S Trentesaux, N Bednarek, and P Morville.
- Unité de réanimation infantile polyvalente, American Memorial Hospital, CHU, Reims, France.
- Arch Pediatr. 1998 May 1; 5 (5): 521-4.
BackgroundDifferent adverse effects induced by vancomycin bolus infusion are described, but cardiac arrest seems rare, in children as in adults.Case ReportTwo infants, 5 and 12 months old, were admitted after cardiac arrest, following vancomycin bolus infusion in excessive dose. They recovered after prompt resuscitation and their short term follow-up was normal.ConclusionTwo mechanisms are invoked: anaphylactic shock and direct cardiovascular toxicity. Both are dose- and infusion rate-dependent, and probably intersubject dependent. Usually, cardiac arrest is promptly reversed by adequate resuscitation. The rules of prescription are: adequate dilution and slow rate of infusion. If any adverse effect occurred, preventive antihistaminic drug therapy should be advised.
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