Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
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Different adverse effects induced by vancomycin bolus infusion are described, but cardiac arrest seems rare, in children as in adults. ⋯ Two mechanisms are invoked: anaphylactic shock and direct cardiovascular toxicity. Both are dose- and infusion rate-dependent, and probably intersubject dependent. Usually, cardiac arrest is promptly reversed by adequate resuscitation. The rules of prescription are: adequate dilution and slow rate of infusion. If any adverse effect occurred, preventive antihistaminic drug therapy should be advised.