• Yuheng Yang, Xiaoping Ye, Binjie Fu, Zhui Li, Yangyang Feng, Yu Zhao, and Hong Liu.
• Department of Vascular Surgery.
• Medicine (Baltimore). 2021 Feb 12; 100 (6): e24570e24570.

RationaleIntravenous pyogenic granuloma (IVPG) is a special type of pyogenic granuloma, and its preoperative diagnosis is difficult. We report a rare case of IVPG that develops in the lumen of the internal jugular vein (IJV). Here, we analyze the imaging characteristics of present case and summarize the imaging characteristics of previous reported cases.Patient ConcernsA 44-year-old man who presented with a growth in the IJV without any symptoms.DiagnosesA diagnosis of IVPG was made, based on the pathological examination after surgery.InterventionsThe patient underwent surgery to excise the vein segment containing the neoplasm.OutcomesThe patient did not present with any complications in the postoperative follow-up period.LessonsFor clinician, IVPG's preoperative diagnosis is difficult. Although histopathology remains the gold standard for diagnosis, the combination of multiple types of imaging examinations is necessary to rule out the differential diagnoses of IVPG.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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