• Jie He, Nan Liu, Wangwang Liu, Wenli Zhou, Qiangfeng Wang, and Hongjie Hu.
• Department of Radiology.
• Medicine (Baltimore). 2021 Feb 12; 100 (6): e24629e24629.

RationaleHemangioblastomas in the kidney are rare. Although a few cases of renal hemangioblastoma (RH) have been reported, the content of these articles mainly focused on clinical and pathological research, with minimal descriptions of radiologic findings. Moreover, there are no descriptions of magnetic resonance imaging (MRI) with enhancement of this condition. Herein, we report 2 cases of RH with computed tomography (CT) and MRI findings.Patient ConcernsTwo patients presented to our institution because of dull pain in the left abdomen, and a mass in the left kidney was found by ultrasound examination in each case. The patient had no special family history. Physical examination revealed no obvious tenderness or percussion pain in the renal and ureteral walking areas, and there was no obvious mass. Routine blood and urine tests were normal, and the serum tumor markers were negative. No obvious lesions were found on imaging of the other body parts.DiagnosisSimilar radiologic findings were observed in both cases and mimicked those of cavernous hemangiomas of the liver, including peripheral nodular enhancement in the corticomedullary phase, progressive centripetal enhancement in the nephrographic and delayed phases, and occasional complete "filling in" in the delayed phase. We made a radiologic diagnosis of renal clear cell carcinoma for patient 1 and suspected renal clear cell carcinoma for patient 2, but the pathological results showed RH.InterventionsGiven the suspicion of renal cell carcinoma, both patients underwent partial nephrectomy.OutcomeThe recovery of the two patients was uneventful, and there was no evidence of local recurrence or metastasis many years after surgery.LessonsRH is a rare benign tumor that can be easily misdiagnosed as clear cell carcinoma. Characteristic CT and MRI manifestations may improve preoperative diagnostic accuracy to avoid surgery or indicate nephron-sparing surgery.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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