• Dagang Yang, Guojuan Liu, Shuang Guo, Huibang Ren, Hongnan Lu, Lihua Zhou, and Longtang Bao.
• Department of Critical Care Medicine, Affiliated Hospital of Inner Mongolia Medical University.
• Medicine (Baltimore). 2021 Feb 12; 100 (6): e24715e24715.

BackgroundSepsis is commonly acute and critical illness with high morbidity and high mortality, and requires timely diagnosis and treatment. Septic patients had elevated serum H-FABP levels, which may correlate with disease severity and mortality. However, previous studies showed that the association between H-FABP and mortality during the sepsis remains unclear. Thus, we performed a study to analyze this relationship.MethodsThe electronic databases such as Cochrane Library, PubMed, Embase, Web of Science, Cochrane Clinical Trials Database, Wanfang Database, and China National knowledge Infrastructure (CNKI) were systematically searched to determine the qualified clinical trials. The study language is limited to English or Chinese. The 2 authors used Cochrane Risk of Bias Tool v.2.0 to independently check the quality of papers and extract relevant data. Comprehensive analysis of data extracted in the research using appropriate statistical methods.ResultsEvaluation of the relationship between the prognosis of patients with sepsis and serum H-FABP is the result of this study.ConclusionThe analysis results of this study can infer that H-FABP may be an independent risk factor for the prognosis of patients with sepsis. It is also helpful for clinical workers to make early evaluation and early treatment of patients with sepsis.Ethics And DisseminationThe conclusions of this meta-analysis study are based on the published evidence. Therefore, moral recognition is unnecessary.Osf Registration NumberDOI: 10.17605/ OSF.IO / 2V4HN.(https://osf.io/2v4hn/).Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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