• Cancer Epidemiol. Biomarkers Prev. · Jul 2014

    Risk of hospitalization for survivors of childhood and adolescent cancer.

    • Anne C Kirchhoff, Mark N Fluchel, Jennifer Wright, Jian Ying, Carol Sweeney, Julia Bodson, Antoinette M Stroup, Ken R Smith, Alison Fraser, and Anita Y Kinney.
    • Authors' Affiliations: Cancer Control and Population Sciences Research Program; Center for Children's Cancer Research; Department of Pediatrics, University of Utah School of Medicine; anne.kirchhoff@hci.utah.edu.
    • Cancer Epidemiol. Biomarkers Prev. 2014 Jul 1; 23 (7): 1280-9.

    BackgroundChildhood cancer survivors may be at increased risk of hospitalization because of cancer-related late effects.MethodsUsing data from population-based research resources in Utah, we identified childhood and adolescent cancer survivors who were diagnosed from 1973 to 2005 (N = 2,571). We selected a comparison cohort based on birth year and sex (N = 7,713). Hospitalizations from 1996 to 2010, excluding pregnancy and delivery, were determined from discharge records. Multivariable regressions were used to evaluate hospitalization admissions, length of stay, and diagnosis for survivors starting five years from diagnosis versus the comparison cohort.ResultsWhen follow-up began in 1996, there were N = 1,499 survivors and N = 7,219 comparisons who were alive and eligible for follow-up. Average follow-up for survivors was 13.5 years (SD = 8.5) and for the comparison 14.0 years (SD = 8.7; P = 0.05). Survivors were hospitalized, on average, 1.62 (SD = 3.37) times contrasted to 0.79 (SD = 1.73) for the comparison cohort. In multivariable analyses, the hazard ratio (HR) of any hospitalization since 1996 was higher for survivors than the comparison cohort [HR, 1.52, 95% confidence interval (CI), 1.31-1.66]. Survivors experienced a higher hospital admission rate [rate ratio (RR) = 1.67; 95% CI, 1.58-1.77] than the comparison cohort. The number of hospitalizations was highest for neuroblastoma (RR = 2.21; 95% CI, 1.84-2.66) and bone tumors (RR = 2.55; 95% CI, 2.14-3.02) in reference to the comparison cohort. Survivors were hospitalized because of blood disorders more often (HR, 14.2; 95% CI, 6.3-32.0).ConclusionsThe risk of hospitalization and lengths of stay are elevated among childhood cancer survivors.ImpactResearch to identify strategies to prevent and manage survivors' health problems in outpatient settings is needed.©2014 American Association for Cancer Research.

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