• Peng Zhang, Mei-Ying Jin, Xu-Yu Song, Zhao Wang, Yue-Hua Jiang, and Chuan-Hua Yang.
• First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250355.
• Medicine (Baltimore). 2021 Feb 5; 100 (5): e24127e24127.

BackgroundIt is well known that morning blood pressure surge increases the risk of myocardial events in the first several hours post-awakening. This meta-analysis was performed to compare the antihypertensive efficacy of morning and bedtime dosing on decreasing morning blood pressure surge.MethodsArticles in 4 databases about clinical trials of ingestion time of antihypertensive drugs were searched and performed a meta-analysis to evaluate the different effects on morning blood pressure and absolute blood pressure (BP) reduction from baseline of between bedtime administration (experimental group) and morning awaking administration (control group).ResultsThe aim of this study is to compare the antihypertensive efficacy of morning and bedtime dosing on decreasing morning blood pressure surge.ConclusionsThe bedtime will provide evidence support for clinicians and patients for reducing morning blood pressure surge.Ethics And DisseminationThis study does not require ethical approval.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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