• Mikkel Rosendahl, Berit Jul Mosgaard, and Claus Høgdall.
• Copenhagen University Hospital, Rigshospitalet, Department of Obstetrics and Gynaecology, Copenhagen, Denmark Mikkel.rosendahl.03@regionh.dk.
• Anticancer Res. 2016 Oct 1; 36 (10): 5373-5379.

AimTo determine if survival in stage I ovarian cancer is influenced by cyst emptying, lymph node resection and chemotherapy.Patients And MethodsA survival analysis of 607 patients with ovarian cancer in stage IA, IA with cyst emptying (IAempty) and IC1 was performed.ResultsThere was no difference in five-year survival between IA (87%) and IC1 (87%) (p=0.899), between IA and IAempty (86%) (p=0.500) nor between IA+IAempty (87%) and IC1 without IAempty (84%) (p=0.527). Five-year survival rate (5YSR) was significantly higher after lymph node resection in stage IA (94% vs. 85%; p=0.01) and IA+IC1 (93% vs. 85%; p=0.004). In multivariate analysis, lymph node resection improved prognosis significantly for all sub-stages, whereas stage and chemotherapy did not affect survival.ConclusionIn stage IA ovarian cancer, controlled cyst emptying without spill does not worsen prognosis. Lymph node resection is associated with improved survival in stage IA and IC1. Chemotherapy should only be offered where randomized controlled studies have shown a benefit.Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

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