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- Fangxiang Mu, Minge Shi, Li Huang, Dafen Wang, and Aiqun Shen.
- Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University.
- Medicine (Baltimore). 2021 Feb 19; 100 (7): e24398e24398.
ObjectiveTo identify the role of estrogen receptor-beta (ER-β) gene +1730G/A (rs4986938) polymorphisms in recurrent pregnancy loss (RPL).MethodsAll relevant case-control studies will be systematically searched in multiple databases including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Internet (CNKI), Wanfang and Cqvip. Both pooled odds rations (ORs) and 95% confidence intervals (CIs) will be used to assess the association between ER-β gene +1730G/A polymorphisms and RPL risk. The publication bias will be evaluated using Egger test.ResultsER-β gene +1730G/A variation may be associated with a higher risk of RPL in Caucasian population.ConclusionsThe findings of this meta-analysis will provide high-quality evidence for the association between ER-β gene +1730G/A polymorphisms and RPL, facilitating clinical practice and further scientific studies.Osf Registration Number10.17605/OSF.IO/EW9FB.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
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