• Eun Jin Kim, Yong Hoon Lee, Jae Seok Park, Jaehee Lee, Shin Yup Lee, Yeonjae Kim, Yong Shik Kwon, Jong Geol Jang, Kyeong-Cheol Shin, KimKyung ChanKCDivision of Pulmonary and Critical Care Medicine, Daegu Catholic university hospital., and Eun Young Choi.
• Division of Pulmonary and Critical Care Medicine, Daegu Catholic university hospital.
• Medicine (Baltimore). 2021 Feb 19; 100 (7): e24437e24437.

AbstractTo describe the clinical and demographic characteristics of critically ill patients with COVID-19 in Daegu, South Korea, and to explore the risk factors for in-hospital mortality in these patients.Retrospective cohort study of 110 critically ill patients with COVID-19 admitted to the ICU in Daegu, South Korea, between February 18 and April 5, 2020. The final date of follow-up was April 20, 2020.A total of 110 patient medical records were reviewed. The median age was 71 years (interquartile range [IQR] = 63-78 years). During the study period, 47 patients (42.7%) died in the hospital. The most common SARS-CoV-2 infection related complication was acute respiratory distress syndrome (ARDS) in 95 patients (86.4%). Of the 79 patients (71.8%) who received invasive mechanical ventilation, 46 (58.2%) received neuromuscular blockade injection, and 19 (24.1%) received ECMO treatment. All patients received antibiotic injection, 99 patients (90%) received hydroxychloroquine, 96 patients (87.3%) received lopinavir-ritonavir antiviral medication, and 14 patients (12.7%) received other antiviral agents, including darunavir-cobicistat and emtricitabine-tenofovir. In the multivariable logistic regression model, the odds ratio of in-hospital death was higher with APACHE II score (OR = 1.126; 95% CI = 1.014-1.252; P  = .027).The in-hospital mortality rate of critically ill patients with COVID-19 was approximately 40%. Higher APACHE II score at admission was an independent risk factor for death in these patients.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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