• Cancan Li, Yiming Du, Huawei Wang, Gaohong Wu, and Xueping Zhu.
• Department of Neonatology, Children's Hospital of Soochow University, China.
• Medicine (Baltimore). 2021 Feb 19; 100 (7): e24624e24624.

RationaleKawasaki Disease (KD) is a self-limiting and acute systemic vasculitis of childhood that leads to coronary artery abnormality in about 25% of untreated cases. KD is extremely rare in neonates. The purpose of this paper is to explore the clinical features and diagnosis and treatment of Neonatal Kawasaki Disease for early identification.Patient ConcernsA 24-day-old male with 3 hours fever and a rash was admitted to our hospital.DiagnosesHe had a fever, rash, cracking of lips, lymph node enlargement in the neck, and distal extremity desquamation.InterventionsThe patient was given intravenous immunoglobulin and aspirin with no complications.OutcomesAfter discharge, the patient was followed up to 1 year old, with good prognosis and no carditis or coronary artery abnormalities.LessonsNeonatal Kawasaki disease is extremely rare, and its clinical manifestation is not typical and easy to be missed. If not treated early, it will potentially give rise to coronary artery aneurysms or expansion, ischemic heart disease, and sudden death. Early diagnosis and treatment are very important.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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