• Ming Yang, Wei Wei Li, Jian Hua Chen, Miao Hang Cui, and Jin Long Liu.
• Department of hepatobiliary surgery, The Affiliated Hospital of Chengde Medical College.
• Medicine (Baltimore). 2021 Feb 19; 100 (7): e24727e24727.

PurposeTo discuss the value of caudate lobectomy in hilar cholangiocarcinoma (HCCA) treatment.MethodsA systematic review was performed in PubMed, MEDLINE database, EMBASE, and Cochrane Library for trials comparing combined caudate lobectomy with controls from January 1, 1990 to December 2, 2020. The outcomes were postoperative radical cure information, survival condition, morbidity, and mortality.ResultTen studies were included. No difference was observed in the morbidity (odd ratio (OR) 0.93, 95% confidence interval (CI) 0.65-1.33) and mortality (OR 1.16, 95% CI 0.55-2.42) between the combined caudate lobectomy and control groups. Hepatectomy combined with caudate lobectomy was associated with higher incidence of radical resection (OR 3.88, 95% CI 2.18-6.90) and longer survival (hazard ratio 0.45, 95% CI 0.38-0.55).ConclusionCombining caudate lobectomy can significantly increase the incidence of radical resection of HCCA and the postoperative survival time. The morbidity and mortality were not increased after the operation. Thus, caudate lobectomy should be included when performing partial hepatectomy for HCCA.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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