• Yue-Tong Wang, Rong-Qiang Zhang, Shu-Fei Wang, Xian-Cheng Li, Nan Zhang, Ya-Feng Zhao, Yu Wang, Xiao-Yong Yu, and Kai Qu.
• School of Basic Medicine.
• Medicine (Baltimore). 2021 Feb 19; 100 (7): e24799e24799.

BackgroundThe combination of Traditional Chinese medicine and Western medicine (TCM+WM) has been widely used in the treatment of glomerulosclerosis, but the results are still controversial. This study will assess the clinical efficacy of TCM+WM for glomerulosclerosis and provide evidence-based medical data via meta-analysis.MethodThe MEDLINE, EMBASE, PubMed, Cochrane Central Registry of Controlled Trials, and multiple Chinese databases (Wan Fang, CNKI, and VIP) were searched for randomized controlled trials (RCT) that compared the effects of WM and TCM+WM. Review Manager 5.3 software was used for the meta-analysis of selected studies, and appropriate tests were performed to determine the quality, heterogeneity and sensitivity of these studies.ResultsSixteen RCTs met the inclusion criteria and were selected for the analysis. Compared with the placebo or WM-treated glomerulosclerosis patients, TCM+WM intervention significantly improved renal function indices including 24-hour urine protein quantity (24 h U-Pro), serum creatinine (Scr), blood urea nitrogen (BUN), creatinine clearance (Ccr). In addition, the serum albumin (ALB), triglyceride (TG), and cholesterol (CHOL) levels were also significantly improved (P < .05) in patients receiving the combination therapy. Finally, the combination of TCM+WM reduced the indices of glomerulosclerosis more effectively compared with WM alone.ConclusionThe combination of TCM+WM can significantly improve the renal function and prognosis of patients with glomerulosclerosis.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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