• Keisuke Sugimoto, Shinji Uejima, Yumiko Uchiyama, Reita Yasue, Kazuya Nambu, Jun Ishikawa, Yoshiro Koma, Takako Akita, Taketomo Toh, and Takehiro Fujimoto.
• Department of Oral and Maxillofacial Surgery, Iwata City Hospital, Iwata.
• Medicine (Baltimore). 2021 Feb 19; 100 (7): e24806e24806.

RationaleOral cancer often causes secondary primary cancers in the upper gastrointestinal tract. However, there are no reports of secondary primary cancers in patients with oral squamous cell carcinoma and malignant lymphoma of the small intestine. This report describes a case of metachronous multiple primary cancers of the tongue and small intestine malignant lymphoma.Patients ConcernsThe patient was admitted to our department with the chief complaint of pain in the right tongue. Partial tongue resection and supraomohyoid neck dissection were performed. One year after surgery, the patient experienced abdominal pain and bloody stools.DiagnosisDiffuse large B-cell lymphoma (DLBCL) was diagnosed via histological examination.InterventionsA terminal ileum resection was performed. Postoperatively, the patient received 6 courses of rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP).OutcomesFive years after his initial diagnosis, there is no evidence of recurrence, metastasis, or other primary cancer.LessonsOral cancer patients should always be followed up owing to a possibility of malignant tumors in other areas.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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