• Medicine · Feb 2021

    Meta Analysis Comparative Study

    Comparative efficacy and safety of complementary and alternative therapies for tubal obstructive infertility: A protocol for network meta-analysis.

    • Shuang-Qian Dong, Xing-Long Zhao, Ying Sun, and Jian-Wei Zhang.
    • Shandong University of Traditional Chinese Medicine, Jinan.
    • Medicine (Baltimore). 2021 Feb 19; 100 (7): e24810e24810.

    BackgroundInfertility is a kind of global disease. Fallopian tubal obstruction is one of the most important causes of female infertility. Complementary and alternative therapies are effective in treating tubal obstructive infertility, but there is no study on a comprehensive comparison among them. So, the purpose of this paper is to evaluate the efficacy and safety of different complementary and alternative therapies for tubal obstructive infertility.MethodsWe will search for randomized controlled trials (RCTs) from the following databases: PubMed, Cochrane Library, EMBASE, Web of Science, Chinese Biomedical Literature Database (SinoMed), Chinese National Knowledge Infrastructure (CNKI), Wanfang database, and VIP database. We will assess the risk of bias of the included studies with the Cochrane tool, and the strength of evidence with the GRADE approach. Both pairwise meta-analyses and network meta-analyses will be performed to examine the relative efficacy and safety of complementary and alternative therapies in the treatment of tubal obstructive infertility.ConclusionOur findings will provide clear evidence based on current available studies, which may lead to some proposals for both patients and researchers.Inplasy Registration NumberINPLASY202110076.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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