• Sunil Gupta, Mayenaaz Sidhu, Xuan Banh, Joseph Bradbear, Karen Byth, Luke F Hourigan, Spiro Raftopoulos, and Michael J Bourke.
• Westmead Hospital, Sydney, NSW.
• Med. J. Aust. 2021 Mar 1; 214 (4): 173-178.

ObjectiveTo describe the clinical and procedural outcomes of per-oral endoscopic myotomy (POEM) for achalasia in Australia.Design, SettingProspective observational study in three Australian tertiary referral centres, 5 May 2014 - 27 October 2019 (66 months).ParticipantsPatients who had undergone POEM for achalasia.Major Outcome MeasuresEckardt scores calculated prior to POEM and six months, one year, and two years after POEM. The primary outcome was clinical success, defined as an Eckardt score of 3 or less without a second intervention.Results142 patients underwent POEM for achalasia; their mean age was 52 years (SD, 18 years), 83 were men (58%), and the median length of hospital stay two days (IQR, 1-3 days). Their mean Eckardt score before POEM was 8.0 (SD, 2.4) and 1.1 (SD, 1.6) six months after POEM; it did not change significantly between six months and two years after POEM (mean monthly increase, 0.014 points; 95% CI, -0.001 to 0.029). A total of 127 patients (89%) improved clinically after POEM. Intra-procedural capnoperitoneum was the only risk factor associated with treatment failure (adjusted hazard ratio, 2.85; 95% CI, 1.08-7.51). Previous treatments - botulinum toxin injection (25 patients, 18%), endoscopic balloon dilatation (69, 49%), and Heller myotomy (14, 10%) - did not affect POEM outcomes. Five patients (4%) experienced major adverse events, including pneumonia, oesophageal leak, empyema and melaena, that were managed during admission and without sequelae.ConclusionsPOEM is an effective treatment for achalasia. Significant reductions in Eckardt scores achieved by six months are sustained at two years. POEM can be both a first line definitive therapy and a salvage therapy for patients not helped by other treatments.© 2021 AMPCo Pty Ltd.

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