• J Nippon Med Sch · Jan 2017

    Review

    Review on Recent Topics in Hypophysitis.

    • Hitoshi Sugihara.
    • Department of Endocrinology, Diabetes and Metabolism, Nippon Medical School.
    • J Nippon Med Sch. 2017 Jan 1; 84 (5): 201-208.

    AbstractThe number of cases of lymphocytic hypophysitis is small, although the condition is not rare. For optimal therapy, the correct diagnosis from imaging, immunological studies, and pathological findings from a pituitary biopsy is important. Recently, anti-Rabphilin antibody has been proposed to be a biomarker for lymphocytic infundibulo-neurohypophysitis. Immunological disorders such as anti-Pit-1 antibody syndrome are similar to the pathogenesis of lymphocytic hypophysitis. Moreover, recent immune checkpoint blockade such ipilimumab has been shown to induce anti-CTLA-4-related hypophysitis. In the future, elucidating the immunological mechanism and establishing a suitable therapy will be necessary for accurate long-term prognosis.

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