• Bojana Beović, May Doušak, João Ferreira-Coimbra, Kristina Nadrah, Francesca Rubulotta, Mirko Belliato, Joana Berger-Estilita, Folusakin Ayoade, Jordi Rello, and Hakan Erdem.
• University Medical Centre Ljubljana, Ljubljana, Slovenia.
• J. Antimicrob. Chemother. 2020 Nov 1; 75 (11): 3386-3390.

BackgroundAntibiotics may be indicated in patients with COVID-19 due to suspected or confirmed bacterial superinfection.ObjectivesTo investigate antibiotic prescribing practices in patients with COVID-19.MethodsWe performed an international web-based survey and investigated the pattern of antibiotic use as reported by physicians involved in treatment of COVID-19. SPSS Statistics version 25 was used for data analysis.ResultsThe survey was completed by 166 participants from 23 countries and 82 different hospitals. Local guidelines for antibiotic use in COVID-19 patients were reported by 61.8% (n = 102) of participants and for 82.9% (n = 136) they did not differ from local community-acquired pneumonia guidelines. Clinical presentation was recognized as the most important reason for the start of antibiotics (mean score = 4.07 and SD = 1.095 on grading scale from 1 to 5). When antibiotics were started, most respondents rated as the highest the need for coverage of atypical pathogens (mean score = 2.8 and SD = 0.99), followed by Staphylococcus aureus (mean score = 2.67 and SD = 1.05 on bi-modal scale, with values 1 and 2 for disagreement and values 3 and 4 for agreement). In the patients on the ward, 29.1% of respondents chose not to prescribe any antibiotic. Combination of β-lactams and macrolides or fluoroquinolones was reported by 52.4% (n = 87) of respondents. In patients in the ICU, piperacillin/tazobactam was the most commonly prescribed antibiotic. The mean reported duration of antibiotic treatment was 7.12 (SD = 2.44) days.ConclusionsThe study revealed widespread broad-spectrum antibiotic use in patients with COVID-19. Implementation of antimicrobial stewardship principles is warranted to mitigate the negative consequences of antibiotic therapy.© The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.

18 keywords...

hide…