The Journal of antimicrobial chemotherapy
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J. Antimicrob. Chemother. · Nov 2020
Observational StudyEffectiveness of remdesivir in patients with COVID-19 under mechanical ventilation in an Italian ICU.
Remdesivir is a prodrug with in vitro activity against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Its clinical efficacy in patients with COVID-19 under mechanical ventilation remains to be evaluated. ⋯ In this study the mortality rate of patients with COVID-19 under mechanical ventilation is confirmed to be high. The use of remdesivir was associated with a significant beneficial effect on survival.
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J. Antimicrob. Chemother. · Nov 2020
Antibiotic use in patients with COVID-19: a 'snapshot' Infectious Diseases International Research Initiative (ID-IRI) survey.
Antibiotics may be indicated in patients with COVID-19 due to suspected or confirmed bacterial superinfection. ⋯ The study revealed widespread broad-spectrum antibiotic use in patients with COVID-19. Implementation of antimicrobial stewardship principles is warranted to mitigate the negative consequences of antibiotic therapy.