• African health sciences · Jun 2016

    Randomized Controlled Trial Comparative Study

    Weight loss improves biomarkers endothelial function and systemic inflammation in obese postmenopausal Saudi women.

    • Shehab Mahmoud Abd El-Kader and Mohammed H Saiem Al-Dahr.
    • Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University.
    • Afr Health Sci. 2016 Jun 1; 16 (2): 533-41.

    BackgroundAlthough postmenopausal associated disorders are important public health problems worldwide, to date limited studies evaluated the endothelial function and systemic inflammation response to weight loss in obese postmenopausal women.ObjectiveThis study was done to evaluate the endothelial function and systemic inflammation response to weight loss in obese postmenopausal Saudi women.Material And MethodsEighty postmenopausal obese Saudi women (mean age 52.64±6.13 year) participated in two groups: Group (A) received aerobic exercise on treadmill and diet whereas, group (B) received no intervention. Markers of inflammation and endothelial function were measured before and after 3 months at the end of the study.ResultsThe values of body mass index(BMI), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), inter-cellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and plasminogen activator inhibitor-1 activity (PAI-1:Ac) were significantly decreased in group (A), while changes were not significant in group (B). Also, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) after treatment.ConclusionWeight loss ameliorates inflammatory cytokines and markers of endothelial function in obese postmenopausal Saudi women.

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