• Nan Li, Dan Liu, Lei Zhang, Linshan Zhao, Fan Guo, and Aimin Zang.
• College of Clinical Medicine, Hebei University, Baoding, Hebei.
• Medicine (Baltimore). 2021 Feb 26; 100 (8): e24865e24865.

BackgroundCancer is a life-threatening condition and also one of the biggest challenges facing human health and the medical community. This meta-analysis was to investigate the effects of music intervention on physiological and psychological responses of patients with cancer.Methods And AnalysisThe following electronic databases will be searched from inception to December 2020: PubMed, EMBASE, Web of Science, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure Database, Chinese Science and the Wanfang Database. We only included music intervention vs placebo in cancer patients and pooled results were summarized by STATA 12.0 software. Two investigators independently selected the studies according to the inclusion and exclusion criteria, extracted the data, and assessed the quality of the selected studies. The existence of statistical heterogeneity would be evaluated by Chi2 test and its extension by the I2 test (I2 > 50% indicates high heterogeneity among studies). Publication bias was ruled out by funnel plot and statistically assessed by Begg test (P > .05 as no publication bias).ResultsThe study results will be published in relevant peer-reviewed journals and key findings will be presented at international scientific meetings.ConclusionOur study aims to systematically assess the effects of music intervention in cancer patients, which will be provide clinical guidance for cancer patients.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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