• Huaiyu Li, Yun Chen, Ziyi Hu, Jiawang Jiang, Jing Ye, Yuliang Zhou, Zhiying Yu, and Haiyi Tang.
• Jiangxi University of Traditional Chinese Medicine, Nanchang.
• Medicine (Baltimore). 2021 Feb 26; 100 (8): e24958e24958.

BackgroundIrritable bowel syndrome (IBS) is the most commonly gastrointestinal diseases. The Rome Foundation's global study on 33 countries shows the total prevalence of IBS under the Rome IV Diagnostic Criteria was 3.8%. It is well established that people with IBS have higher levels of anxiety and depression. The impact of the acupuncture associated with anxiety and depression has been widely studied in Western countries. Acupuncture may be a promising choice for the treatment of anxiety and depression in IBS.MethodsRCTs of acupuncture for depression and anxiety in IBS will be searched in the relevant database, including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Database, Chinese Biomedical Literature Database (CBM), and Chinese Scientific Journal Database (VIP database). The studies of electronic searches will be exported to EndNote V.9.1 software. We will run meta-analyses using the Review Manager (RevMan) V.5.3 software. Any disagreement will be solved in consultation with a third reviewer.ResultsOur study aims to explore the efficacy of acupuncture for depression and anxiety in IBS and to provide up-to-date evidence for clinical of IBS.ConclusionThis study will perform a comprehensive systematic review and meta-analysis on the efficacy of acupuncture for depression and anxiety in IBS, making up for the lack of relevant evidence of the clinical use of acupuncture.Inplasy Registration NumberINPLASY 202120014.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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