• Nour Chams, Sana Chams, Reina Badran, Ali Shams, Abdallah Araji, Mohamad Raad, Sanjay Mukhopadhyay, Edana Stroberg, Eric J Duval, Lisa M Barton, and Inaya Hajj Hussein.
• Geriatric Division, Department of Internal Medicine, Beaumont Health System, Royal Oak, MI, United States.
• Front Public Health. 2020 Jan 1; 8: 383.

AbstractSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that is responsible for the 2019-2020 pandemic. In this comprehensive review, we discuss the current published literature surrounding the SARS-CoV-2 virus. We examine the fundamental concepts including the origin, virology, pathogenesis, clinical manifestations, diagnosis, laboratory, radiology, and histopathologic findings, complications, and treatment. Given that much of the information has been extrapolated from what we know about other coronaviruses including severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), we identify and provide insight into controversies and research gaps for the current pandemic to assist with future research ideas. Finally, we discuss the global response to the coronavirus disease-2019 (COVID-19) pandemic and provide thoughts regarding lessons for future pandemics.Copyright © 2020 Chams, Chams, Badran, Shams, Araji, Raad, Mukhopadhyay, Stroberg, Duval, Barton and Hajj Hussein.

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