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Nihon Shokakibyo Gakkai Zasshi · Jun 2014
Case Reports[Two cases of dabigatran-induced esophageal ulcer indicating the usefulness of drug administration guidance].
- Koichi Izumikawa, Tomoki Inaba, Shou Mizukawa, Yusuke Kawai, Ichiro Sakakihara, Shigenao Ishikawa, Masatsugu Miyoshi, Masaki Wato, and Kozo Kawai.
- Department of Gastroenterology, Kagawa Prefectural Central Hospital.
- Nihon Shokakibyo Gakkai Zasshi. 2014 Jun 1; 111 (6): 1096-104.
AbstractHere we report two cases of dabigatran-induced esophageal ulcer. Case 1 was a 67-year-old man who presented with heartburn that developed a month after dabigatran administration. Case 2 was an 81-year-old woman who presented with epigastralgia that developed within a few days of dabigatran administration. Endoscopic findings were similar in both cases, including shallow esophageal ulcers covered with a thin whitish membrane. The patients were advised to consume the drug with plenty of water during meals and to remain in a sitting position for 30 min after consumption. This method successfully decreased their symptoms and ulcers, indicating that drug administration guidance is extremely effective in managing dabigatran-induced esophageal injury.
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