• Acta cirúrgica brasileira · Nov 2017

    Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusion.

    • Mieko Okada, Luiz Fernando Reis Falcão, David Ferez, José Luiz Martins, Paolo Ruggero Errante, Francisco Sandro Menezes Rodrigues, Afonso Caricati-Neto, Márcia Marinho, Guilherme Fenelon, and Itamar Souza Oliveira-Júnior.
    • Fellow PhD degree, Postgraduate Program in Translational Medicine, Universidade Federal de São Paulo (UNIFESP), Brazil. Acquisition, analysis and interpretation of data; technical procedures; statistical analysis, manuscript writing.
    • Acta Cir Bras. 2017 Nov 1; 32 (11): 964-972.

    PurposeTo investigate the effects of atenolol in inflammatory mediator and oxidative stress in a myocardial injury by intestinal ischemia/reperfusion in rat model.MethodsAdult Wistar male rats were randomly (n=8), anesthetized and divided in: Sham: submitted to operation only; group SS+IR: intravenous saline infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and open for 120 minutes (reperfusion); group AT+IR: intravenous atenolol infusion (2 mg/kg) following superior mesenteric artery occlusion during 60 minutes (ischemia) and open for 120 minutes (reperfusion); and group AT+I+AT+R: intravenous atenolol infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and in the time 45 minutes other atenolol doses were administrated and the artery was open for 120 minutes (reperfusion), all animals were submitted to muscular relaxation for mechanical ventilation. In the end of experiment the animals were euthanized and the hearts tissue were morphology analyzed by histology and malondialdehyde by ELISA, and the plasma were analyzed for tumor necrosis factor-alpha by ELISA.ResultsThe group SS+IR demonstrated the higher malondialdehyde levels when compared with the atenolol treated-groups (p=0.001) in the heart tissue. The tumor necrosis factor-alpha level in plasma decrease in the treated groups when compared with SS+IR group (p=0.001). Histology analyses demonstrate pyknosis, edema, cellular vacuolization, presence of inflammatory infiltrate and band contraction in the heart tissue of the rats.ConclusionAtenolol significantly reduce the degree of cardiac damage after intestinal ischemia-reperfusion.

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