• N Tajik, S A Keshavarz, F Masoudkabir, M Djalali, H Hale Sadrzadeh-Yeganeh, M R Eshraghian, M Chamary, Z Ahmadivand, T Yazdani, and M H Javanbakht.
• Nutrition and Biochemistry Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
• J. Endocrinol. Invest. 2013 Apr 1; 36 (4): 211-5.

BackgroundObesity is associated with lowgrade systemic inflammation which has been linked to the increased risk of cardiovascular disease and Type 2 diabetes in obese patients.AimTo evaluate changes in pro/anti-inflammatory adipocytokines and metabolic profile after moderate diet-induced weight loss.Subjects And MethodsTwenty-nine pre-menopausal obese women (body mass index ≥30 kg/m2) aged 21 to 54 years without diabetes, hypertension, or hyperlipidemia, were enrolled in this study. We measured anthropometric parameters, lipid and glucose profiles, interleukin (IL)-6, IL-10, and IL-18 in obese women, who then entered a medically supervised program aimed at reducing body weight by 10% or more. Obese women restricted their caloric intake (by 500-1000 kcal/day) and consumed 50 g/day of a fiber supplement (Slim Last Powder) for 12 weeks.ResultsBy completing the dietary intervention program, weight (Δ = -10.0%, p<0.0001), body mass index, waist circumference, triceps skinfold thickness, total cholesterol, triglyceride, and fasting plasma glucose significantly decreased, while HDL-cholesterol significantly increased. While plasma levels of IL-6 and IL-18 decreased by 27% after 12 weeks, no significant change was observed in circulating levels of IL-10.ConclusionOur study suggests that an improved body composition induced by restriction of energy intake is associated with favorable serum concentrations of IL-6 and IL-18 in obese women. However, the anti-inflammatory IL-10 is not affected by a moderate weight decrease.

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