• Med. J. Aust. · Nov 1978

    Comparative Study

    Control of oral anticoagulants by the prothrombin time: a plea for uniformity.

    • B Bain, T Forster, and B Sleigh.
    • Med. J. Aust. 1978 Nov 4; 2 (10): 459-61.

    AbstractSix trromboplastins commonly used for prothrombin time determinations were studied. Prothrombin times of patients who were receiving oral anticoagulant therapy varied widely, depending on the origin of the thromboplastins. The therapeutic range which is recommended with one thromboplastin is often quite different from that recommended with another, and as a result, the therapeutic ranges of different institutions may show no overlap. Management of patients and comparison of therapeutic results would be facilitated if all thromboplastins in use in Australia were standardized by comparison with the Australian Reference Thromboplastin.

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