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Case Reports
Plasmapheresis in the treatment of thrombotic thrombocytopenic purpura: a report of five cases.
- P F Ryan, I A Cooper, and B G Firkin.
- Med. J. Aust. 1979 Feb 10; 1 (3): 69-72.
AbstractThrombotic thrombocytopenic purpura, an acute clinical disorder of uncertain aetiology, has previously been associated with almost 100% mortality. Dramatic response to exchange transfusion has been reported, and there is some evidence that a circulating immune complex may be involved in the pathogenesis. Therefore, it was decided to employ large-volume plasma exchange by means of a continuous-flow cell separator in the management of five patients with this disease. Three patients showed a dramatic response, which was manifested by rapid correction of the neurological deficit and of the abnormalities in laboratory findings. We conclude that the thrombotic thrombocytopenic syndrome should be regarded as an indication for emergency plasma exchange.
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