• I M Bowdler and W Seeling.
• Universitätsklinik für Anästhesiologie, Klinikum der Universität, Steinhövelstraße 9, W-7900, Ulm.
• Schmerz. 1993 Jun 1;7(2):97-106.

AbstractAt present, intramuscular application of opioids given on request is the most widespread form of postoperative analgesia. This method is widely recognized as often being inadequate, however. As advanced techniques of pain management, such as patient-controlled analgesia, are not generally available, the question arises as to whether non-opioid analgesics should routinely be used in order to improve this situation. A review of the literature indicates that apart from when used following abdominal surgery, in particular, operations on the biliary tract, non-steroidal anti-inflammatory drugs (NSAIDS) offer effective postoperative pain control. Following minor surgery, the quality of analgesia can be better than that achieved with the weak opioids. The discrepancy between biliary tract operations and all other forms of surgery raises the question whether in the former case pain may have been partly due to spasms of visceral smooth muscle and hence be less readily amenable to the action of NSAIDS. A potential problem with the perioperative use of NSAIDS is that they inhibit platelet aggregation. Apart from tonsillectomy, there are no reports of increased intra- or postoperative bleeding when these drugs have been used for minor surgery, and only isolated reports following major operations. Despite these results, it must be borne in mind that most studies have been carried out on patients of ASA groups I and II and that conclusions drawn from the literature are not necessarily representative for the elderly and for patients with organ failure. Alternative substances have received relatively little attention. Of these, the pyrazolone derivative, metamizol, may well prove to be of value for patients in whom the use of NSAIDS is contraindicated or relatively ineffective such as after biliary tract surgery.

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