• Int J Gynaecol Obstet · Jun 2016

    Randomized Controlled Trial

    Randomized controlled trial of tranexamic acid among parturients at increased risk for postpartum hemorrhage undergoing cesarean delivery.

    • Nambiath Sujata, Raj Tobin, Ranjeet Kaur, Anjila Aneja, Mona Khanna, and Vijay M Hanjoora.
    • Department of Anaesthesia, Max Hospital, Saket, New Delhi, India. Electronic address: drnambiath@yahoo.com.
    • Int J Gynaecol Obstet. 2016 Jun 1; 133 (3): 312-5.

    ObjectiveTo assess the effects of tranexamic acid among patients undergoing cesarean delivery who were at high risk of postpartum hemorrhage.MethodsBetween August 1, 2012, and April 30, 2013, a randomized controlled trial was performed at a tertiary care center in India. Women undergoing an elective or emergency cesarean delivery who were at high risk for postpartum hemorrhage were enrolled. They were randomly assigned using sealed, opaque envelopes to receive 10mg/kg tranexamic acid or normal saline 10min before skin incision. Anesthesiologists were not masked to group assignment, but patients and obstetricians were. The primary outcome was need for additional uterotonic drugs within 24h after delivery. Analyses were by intention to treat.ResultsThirty patients were assigned to each group. Additional uterotonic drugs were required in 7 (23%) patients assigned to tranexamic acid and 25 (83%) patients in the control group (P<0.001).ConclusionIntravenous tranexamic acid, administered before skin incision, significantly reduced the requirement for additional uterotonics among women at increased risk for postpartum hemorrhage. Clinical Trials Registry India: CTRI/2015/05/005752.Copyright © 2016 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

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