• Ann Fr Anesth Reanim · Jan 2012

    Review

    [Prevention of postoperative hyperalgesia].

    • C Mamie.
    • Unité d'anesthésie pédiatrique, division d'anesthésiologie, hôpitaux universitaires de Genève, Suisse. chantal.mamie@hcuge.ch
    • Ann Fr Anesth Reanim. 2012 Jan 1;31(1):e39-42.

    AbstractThree types of hyperalgesia can occur during the postoperative period: primary hyperalgesia, which disappears with wound healing, secondary or central hyperalgesia, which can lead to chronic pain, and opiate-induced hyperalgesia. Different drugs, most of which are NMDA receptors antagonists, are used to decrease or prevent the risk of central or opiate-induced hyperalgesia. However, it is difficult to determine whether they are really effective and at which dosage: the results of most published studies are difficult to interpret because of methodological problems. The two most frequent of those are: absence of objective measurement of secondary hyperalgesia and difficulties targeting an at risk population.Copyright © 2011 Société française d’anesthésie et de réanimation (Sfar). Published by Elsevier SAS. All rights reserved.

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