• Clinical imaging · May 2016

    Prostate cancer: correlation of intravoxel incoherent motion MR parameters with Gleason score.

    • Dal Mo Yang, Hyun Cheol Kim, Sang Won Kim, Geon-Ho Jahng, Kyu Yeoun Won, Sung Jig Lim, and Jang-Hoon Oh.
    • Department of Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea. Electronic address: dmy2988@daum.net.
    • Clin Imaging. 2016 May 1; 40 (3): 445-50.

    PurposeTo evaluate the potential of intravoxel incoherent motion (IVIM) imaging to predict histological prognostic parameters by investigating whether IVIM parameters correlate with Gleason score.Materials And MethodsThe institutional review board approved this retrospective study, and informed consent was waived. A total of 41 patients with histologically proven prostate cancer who underwent prostate MRI using a 3T MRI machine were included. For eight diffusion-weighted imaging b-values (0, 10, 20, 50, 100, 200, 500, and 800s/mm(2)), a spin-echo echo-planar imaging sequence was performed. D, f, D(⁎), and ADCfit values were compared among three groups of patients with prostate cancer: Gleason score 6 (n=9), 7 (n=16), or 8 or higher (n=16). Receiver operating characteristic (ROC) curves were generated for D, f, D(⁎), and ADCfit to assess the ability of each parameter to distinguish cancers with low Gleason scores from cancers with intermediate or high Gleason scores.ResultsPearson's coefficient analysis revealed significant negative correlations between Gleason score and ADCfit (r=-0.490, P=.001) and Gleason score and D values (r=-0.514, P=.001). Gleason score was poorly correlated with f (r=0.168, P=.292) and D(⁎) values (r=-0.108, P=.500). The ADCfit and D values of prostate cancers with Gleason scores 7 or ≥8 were significantly lower than values for prostate cancers with Gleason score 6 (P<.05). ROC curves were constructed to assess the ability of IVIM parameters to discriminate prostate cancers with Gleason score 6 from cancers with Gleason scores 7 or ≥8. Areas under the curve were 0.671 to 0.974. ADCfit and D yielded the highest Az value (0.960-0.956), whereas f yielded the lowest Az value (0.633).ConclusionsThe pure molecular diffusion parameter, D, was the IVIM parameter that best discriminated prostate cancers with low Gleason scores from prostate cancers with intermediate or high Gleason scores.Copyright © 2016 Elsevier Inc. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…