• Özge Besci, Dilek Başer, İsmail Öğülür, Ayşe Cansu Berberoğlu, Ayça Kıykım, Tolga Besci, Asım Leblebici, Hülya Ellidokuz, Perran Boran, Eren Özek, Goncagül Haklar, Ahmet Özen, Safa Barış, and Elif Aydıner.
• Department of Pediatric Allergy-Immunology, Faculty of Medicine, Marmara University, İstanbul, Turkey
• Turk J Med Sci. 2021 Aug 30; 51 (4): 1814-1824.

Background/AimEstablished reference values are critical for the interpretation of immunologic assessments. In particular, the proportion and absolute counts of T- and B- cell subpopulations are subject to change with age and ethnicity. We aimed to establish age- specific reference values for lymphocyte subsets using updated immunophenotyping panels.Materials And MethodsWe studied a total of 297 healthy Turkish subjects aged 0 to 50 years, stratified into major age brackets in a cluster factor of 10 per age-group. The predetermined age intervals contained randomly allocated participants enrolled over a period of 6 months, who were homogenously distributed by sex. We analyzed a complete blood count test and simultaneously with detailed immunophenotyping enumerated the percent and absolute cell counts of lymphocyte subsets.ResultsThe percentage and absolute counts of lymphocyte subsets show a marked surge across the age-span. T helper, T cytotoxic, and the natural killer cell numbers were increasing from birth until 6 months, followed by a gradual decrease thereafter. B cell numbers were rising until 2 years, followed by a gradual decrease for the upcoming years, accompanied by a steady expansion of unclass-switched- and class-switched- B cells.ConclusionWe provide updated extensive reference intervals for lymphocyte subpopulations in Turkish people.This work is licensed under a Creative Commons Attribution 4.0 International License.

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