• Ana Claudia Pelissari Kravchychyn, CamposRaquel Munhoz da SilveiraRMDSPostgraduate Program of Interdisciplinary Health Sciences, Federal University of Sao Paulo, Santos, Brazil., Luciana Oliveira E Silva, Yasmin Alaby Martins Ferreira, Flávia Campos Corgosinho, MasquioDeborah Cristina LandiDCLSao Camilo University Center, Sao Paulo, Brazil., Sofia Emanuelle de Castro Ferreira Vicente, Lila Missae Oyama, Lian Tock, Marco Túlio de Mello, Sérgio Tufik, David Thivel, and Ana Raimunda Dâmaso.
• Postgraduate Program of Nutrition, Federal University of Sao Paulo; Paulista Medicine School, Sao Paulo, Brazil. Electronic address: anapelissari@hotmail.com.
• Nutrition. 2021 Jul 1; 87-88: 111188.

ObjectiveThe aim of this study was to investigate the association between the magnitude of weight loss (WL) and serum concentrations of the main adipocytokines and appetite-regulating hormones in adolescents with obesity.MethodsAfter completion of informed consent,108 adolescents with obesity (14-19 y of age; postpubertal) were submitted to clinical, nutritional, psychological, physical exercise, and physiotherapy support for 1 y. Body composition (BC) and plasma levels of neuropeptides (neuropeptide Y [NPY], agouti-related peptide [AgRP], and α-melanocyte-stimulating hormone [α-MSH]) and leptin were measured at baseline and post-intervention.ResultsAfter therapy, adolescents who lost <10% body weight and <10% body weight (were compared. Both groups presented improvements in BC and reduced leptin. The Δα-MSH, Δα-MSH/AgRP ratio, and Δα-MSH/NPY ratio were lower and AgRP and NPY variations were higher in the low weight loss group. The leptin concentration was close to normal in the high weight loss only. The ΔWeight, Δα-MSH and Δleptin were associated with body fat loss by multiple linear regressions for all samples.ConclusionWeight loss >10% seems to reverse obesity-induced hyperleptinemia while stabilizing the neuropeptides that control appetite in adolescents with obesity. We were able to produce a prognostic mathematical model to predict body fat loss using weight, leptin, and α-MSH variations.Copyright © 2021. Published by Elsevier Inc.

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